È possibile condurre studi clinici durante una pandemia? L’esempio di uno studio sull’idrossiclorochina
Claudia Lilli, Annibale Biggeri, Chiara Zingaretti, Bernadette Vertogen, Valeria Frassineti, Roberto Vespignani, Veruska Grossi, Caterina Florescu, Laura Matteucci, Chiara Pazzi, Alberto Bongiovanni, Francesco Limarzi, Valentina Fausti, Lucia Bertoni, Caterina Donati, Francesca Galardi, Nicola Gentili, Francesco Mazza, Giovanni Martinelli, Oriana Nanni
Introduction
Hydroxychloroquine (HCQ), a drug normally used to treat malaria and certain autoimmune disorders, was reported to have antiviral activity in vitro against coronaviruses – and specifically SARS-CoV-2 – by researchers of the Wuhan Institute of Virology, China, at the beginning of February, early on in the COVID-19 pandemic.1 The proposed mechanism of action is that it blocks virus infection by increasing endosomal pH required for virus cell fusion and glycosylation of…
